Peroxisome proliferator-activated receptor ???? (PPAR ????), a member of the nuclear receptor superfamily, is a ligand-activated\ntranscription factor that plays an important role in the control of a variety of physiological processes. The last decade has witnessed\nan increasing interest for the role played by the agonists of PPAR ???? in antiangiogenesis, antifibrosis, anti-inflammation effects and\nin controlling oxidative stress response in various organs. As the pathologic mechanisms of major blinding diseases, such as agerelated\nmacular degeneration (AMD), diabetic retinopathy (DR), keratitis, and optic neuropathy, often involve neoangiogenesis\nand inflammation- and oxidative stress-mediated cell death, evidences are accumulating on the potential benefits of PPAR ???? to\nimprove or prevent these vision threatening eye diseases. In this paper we describe what is known about the role of PPAR ???? in the\nocular pathophysiological processes and PPAR ???? agonists as novel adjuvants in the treatment of eye diseases.
Loading....